Solution NMR

NMR structures of dimeric transmembrane domain of the receptor tyrosine kinase EphA1 in lipid bicelles at pH 4.3


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Ephrin type-A receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 38 amino acids
Theoretical weight: 3.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P21709 (Residues: 536-573; Coverage: 4%)
Gene names: EPH, EPHA1, EPHT, EPHT1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 93%
Refinement method: simulated annealing
Chemical shifts: BMR15728  
Expression system: Escherichia coli