› 2jry

Solution NMR

Structure and Sodium Channel Activity of an Excitatory I1-Superfamily Conotoxin

Released:
DOI: 10.2210/pdb2jry/pdb
PDB entry 2jry coloured by chain, ensemble of 20 models, front view.
PDB entry 2jry coloured by chain, ensemble of 20 models, side view.
PDB entry 2jry coloured by chain, ensemble of 20 models, top view.
Source organism: Conus radiatus
Primary publication:
Structure and sodium channel activity of an excitatory I1-superfamily conotoxin.
Buczek O, Wei D, Babon JJ, Yang X, Fiedler B, Chen P, Yoshikami D, Olivera BM, Bulaj G, Norton RS
Biochemistry 46 9929-40 (2007)
PMID: 17696362

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182229 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Iota-conotoxin RXIA Chain: A
Molecule details ›
Chain: A
Length: 46 amino acids
Theoretical weight: 4.99 KDa
Source organism: Conus radiatus
UniProt:
  • Canonical: Q7Z094 (Residues: 1-46; Coverage: 100%)
Sequence domains: Conotoxin I-superfamily
Structure domains: Omega-AgatoxinV

Ligands and Environments

No bound ligands
2 modified residues:
Ligand HYP 3 x HYP
Ligand DPN 1 x DPN

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing

Quick links

Citations

16 review citations

Conus venom peptide pharmacology.
Lewis et al. (2012)
15 more

4 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
3 more