› 2jo0

Solution NMR

The solution structure of the monomeric species of the C terminal domain of the CA protein of HIV-1

Released:
DOI: 10.2210/pdb2jo0/pdb
PDB entry 2jo0 coloured by chain, ensemble of 30 models, front view.
PDB entry 2jo0 coloured by chain, ensemble of 30 models, side view.
PDB entry 2jo0 coloured by chain, ensemble of 30 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Flexibility in HIV-1 assembly subunits: solution structure of the monomeric C-terminal domain of the capsid protein.
Alcaraz LA, del Alamo M, Barrera FN, Mateu MG, Neira JL
Biophys J 93 1264-76 (2007)
PMID: 17526561

Function and Biology Details

Reaction catalysed: 
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179373 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CCHC-type domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 9.56 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q699E2 (Residues: 3-88; Coverage: 64%)
Gene name: gag
Sequence domains: Gag protein p24 C-terminal domain
Structure domains: Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

The structural biology of HIV assembly.
Ganser-Pornillos et al. (2008)
6 more

2 mentions without citation

Flexibility in HIV-1 assembly subunits: solution structure of the monomeric C-terminal domain of the capsid protein.
Alcaraz et al. (2007)
1 more