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Solution NMR

Solution structure of a ERCC1-XPA heterodimer

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA excision repair protein ERCC-1 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 15.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07992 (Residues: 96-214; Coverage: 40%)
Gene name: ERCC1
Sequence domains: Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
Structure domains: Rossmann fold
DNA repair protein complementing XP-A cells Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P23025 (Residues: 67-80; Coverage: 5%)
Gene names: XPA, XPAC

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided