PDB 2jiv biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1

Download 3D Visualisation

Assembly Name: Epidermal growth factor receptor
hide full assembly name

Multimeric state: monomeric

Accessible surface area: 13683.82 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-132671

$Monomeric assembly 1 of PDB entry 2jiv coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Epidermal growth factor receptor;</li> <li class='image_legend_li'>1 copy of N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 2jiv coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Epidermal growth factor receptor;</li> <li class='image_legend_li'>1 copy of N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 2jiv coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Epidermal growth factor receptor;</li> <li class='image_legend_li'>1 copy of N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2 (preferred)

Download 3D Visualisation

Assembly Name: Epidermal growth factor receptor
hide full assembly name

Multimeric state: monomeric

Accessible surface area: 13395.15 Å²

Buried surface area: 176.08 Å²

Dissociation area: 32.9 Å²

Dissociation energy (ΔG^diss): 3.84 kcal/mol

Dissociation entropy (TΔS^diss): -0.83 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-132671

$Monomeric assembly 2 of PDB entry 2jiv coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Epidermal growth factor receptor;</li> <li class='image_legend_li'>1 copy of N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide;</li> <li class='image_legend_li'>1 copy of CHLORIDE ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 2jiv coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Epidermal growth factor receptor;</li> <li class='image_legend_li'>1 copy of N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide;</li> <li class='image_legend_li'>1 copy of CHLORIDE ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 2jiv coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Epidermal growth factor receptor;</li> <li class='image_legend_li'>1 copy of N-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide;</li> <li class='image_legend_li'>1 copy of CHLORIDE ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Epidermal growth factor receptor

Chains: A, B
Length: 328 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Canonical: P00533 (Residues: 695-1022; Coverage: 28%)

Gene names: EGFR, ERBB, ERBB1, HER1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:

Protein kinase-like domain superfamily
Protein kinase domain
Tyrosine-protein kinase, catalytic domain
Serine-threonine/tyrosine-protein kinase, catalytic domain
Protein kinase, ATP binding site
Tyrosine-protein kinase, active site

CATH:

Phosphorylase Kinase; domain 1
Transferase(Phosphotransferase) domain 1

Epidermal growth factor receptor in PDB entry 2jiv, assembly 2, front view.

Epidermal growth factor receptor in PDB entry 2jiv, assembly 2, side view.

Epidermal growth factor receptor in PDB entry 2jiv, assembly 2, top view.

FASTA Sequence


    >pdb|2jiv|A B

SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQG

PDBe-KB: UniProt Coverage View: P00533

Molecule details ›

Download

FASTA (Protein chains A, B)
Archive mmCIF file
Updated mmCIF file
PDB file
PDB header
PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

Search similar proteins

Similar 3D structures (PDBeFold)
Similar sequences

BLAST P00533 (UniProt)

Protein Data Bank in Europe

Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272

Quick links

Assemblies

Assembly 1

Assembly 2 (preferred)

Macromolecules

Search similar proteins

Quick links

PDBe › 2jiv › Structure analysis

Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272

Quick links

Assemblies

Assembly 1

Assembly 2 (preferred)

Macromolecules

Search similar proteins

Quick links

2jiv › Structure analysis