X-ray diffraction
3.5Å resolution

Crystal structure of EGFR kinase domain T790M mutation in compex with HKI-272

Source organism: Homo sapiens
Entry authors: Yun C-H, Mengwasser KE, Toms AV, Li Y, Woo MS, Greulich H, Wong K-K, Meyerson M, Eck MJ

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Epidermal growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 328 amino acids
Theoretical weight: 37.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P00533 (Residues: 695-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 56.087Å b: 98.989Å c: 73.326Å
α: 90° β: 109.94° γ: 90°
R R work R free
0.253 0.251 0.284
Expression system: Spodoptera frugiperda