X-ray diffraction
2.32Å resolution

The crystal structure of the kinase domain of the protein kinase C theta in complex with NVP-XAA228 at 2.32A resolution.

Source organism: Homo sapiens
Entry authors: Stark W, Bitsch F, Berner A, Buelens F, Graff P, Depersin H, Geiser M, Knecht R, Rahuel J, Rummel G, Schlaeppi JM, Schmitz R, Strauss A, Wagner J

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Protein kinase C theta type Chains: A, B
Molecule details ›
Chains: A, B
Length: 352 amino acids
Theoretical weight: 41.82 KDa
Source organism: Homo sapiens
  • Canonical: Q04759 (Residues: 361-706; Coverage: 49%)
Gene names: PRKCQ, PRKCT
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P65
Unit cell:
a: 152.172Å b: 152.172Å c: 74.837Å
α: 90° β: 90° γ: 120°
R R work R free
0.188 0.186 0.221