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Tryptophan Synthase Q114N mutant in complex with Compound II

X-ray diffraction
1.8Å resolution
PDB entry 2j9y coloured by chain, front view.
PDB entry 2j9y coloured by chain, side view.
PDB entry 2j9y coloured by chain, top view.
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tryptophan synthase
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Multimeric state: hetero tetramer
Accessible surface area: 42330.12 Å2
Buried surface area: 8477.16 Å2
Dissociation area: 2,456.46 Å2
Dissociation energy (ΔGdiss): 4.91 kcal/mol
Dissociation entropy (TΔSdiss): 27.17 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-133696

Macromolecules

Tryptophan synthase alpha chain
Chain: A
Length: 268 amino acids
Theoretical weight: 28.7 KDa
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Expression system: Escherichia coli
UniProt:
  • Canonical: P00929 (Residues: 1-268; Coverage: 100%)
Gene names: STM1727, trpA
Pfam: Tryptophan synthase alpha chain
InterPro:
CATH: Aldolase class I
SCOP: Tryptophan biosynthesis enzymes
Tryptophan synthase alpha chain in PDB entry 2j9y, assembly 1, front view.
Tryptophan synthase alpha chain in PDB entry 2j9y, assembly 1, side view.
Tryptophan synthase alpha chain in PDB entry 2j9y, assembly 1, top view.
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Tryptophan synthase beta chain
Chain: B
Length: 397 amino acids
Theoretical weight: 42.9 KDa
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Expression system: Escherichia coli
UniProt:
  • Canonical: P0A2K1 (Residues: 1-397; Coverage: 100%)
Gene names: STM1726, trpB
Pfam: Pyridoxal-phosphate dependent enzyme
InterPro:
CATH: Rossmann fold
Tryptophan synthase beta chain in PDB entry 2j9y, assembly 1, front view.
Tryptophan synthase beta chain in PDB entry 2j9y, assembly 1, side view.
Tryptophan synthase beta chain in PDB entry 2j9y, assembly 1, top view.
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