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CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX

X-ray diffraction
2.01Å resolution
PDB 2j95 coloured by chain and viewed from the front.
PDB 2j95 coloured by chain and viewed from the side.
PDB 2j95 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 13900 Å2
Buried surface area: 2800 Å2
Dissociation area: 900 Å2
Dissociation energy (ΔGdiss): 10 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -26 kcal/mol
Symmetry number: 1

Macromolecules

Activated factor Xa heavy chain
Chain: A
Length: 254 amino acids
Theoretical weight: 28.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 235-488; Coverage: 56%)
Gene name: F10
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
PDB 2j95 contains 1 copy of Activated factor Xa heavy chain in assembly 1. This protein is highlighted and viewed from the front.
PDB 2j95 contains 1 copy of Activated factor Xa heavy chain in assembly 1. This protein is highlighted and viewed from the side.
PDB 2j95 contains 1 copy of Activated factor Xa heavy chain in assembly 1. This protein is highlighted and viewed from the top.
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Factor X light chain
Chain: B
Length: 134 amino acids
Theoretical weight: 15.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 46-179; Coverage: 29%)
Gene name: F10
Pfam:
InterPro:
CATH: Laminin
SCOP: EGF-type module
PDB 2j95 contains 1 copy of Factor X light chain in assembly 1. This protein is highlighted and viewed from the front.
PDB 2j95 contains 1 copy of Factor X light chain in assembly 1. This protein is highlighted and viewed from the side.
PDB 2j95 contains 1 copy of Factor X light chain in assembly 1. This protein is highlighted and viewed from the top.
Molecule details ›

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