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STRUCTURE OF 17-EPIESTRIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5

X-ray diffraction
1.8Å resolution
PDB entry 2j7y coloured by chain, front view.
PDB entry 2j7y coloured by chain, side view.
PDB entry 2j7y coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Estrogen receptor beta and Nuclear receptor coactivator 5
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Multimeric state: hetero dimer
Accessible surface area: 10988.92 Å2
Buried surface area: 3184.3 Å2
Dissociation area: 394.47 Å2
Dissociation energy (ΔGdiss): 2.15 kcal/mol
Dissociation entropy (TΔSdiss): 6.41 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-178981

Macromolecules

Estrogen receptor beta
Chain: A
Length: 255 amino acids
Theoretical weight: 28.69 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62986 (Residues: 255-509; Coverage: 48%)
Gene names: Erbeta, Esr2, Nr3a2
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Estrogen receptor beta in PDB entry 2j7y, assembly 1, front view.
Estrogen receptor beta in PDB entry 2j7y, assembly 1, side view.
Estrogen receptor beta in PDB entry 2j7y, assembly 1, top view.
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Nuclear receptor coactivator 5
Chain: B
Length: 17 amino acids
Theoretical weight: 1.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9HCD5 (Residues: 338-354; Coverage: 3%)
Gene names: KIAA1637, NCOA5
Nuclear receptor coactivator 5 in PDB entry 2j7y, assembly 1, front view.
Nuclear receptor coactivator 5 in PDB entry 2j7y, assembly 1, side view.
Nuclear receptor coactivator 5 in PDB entry 2j7y, assembly 1, top view.
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