2j7t

X-ray diffraction
2Å resolution

Crystal structure of human serine threonine kinase-10 bound to SU11274

Released:
Source organism: Homo sapiens
Entry authors: Pike ACW, Rellos P, Fedorov O, Das S, Debreczeni J, Sobott F, Watt S, Savitsky P, Eswaran J, Turnbull AP, Papagrigoriou E, Ugochukwa E, Gorrec F, Umeano CC, von Delft F, Arrowsmith CH, Edwards A, Weigelt J, Sundstrom M, Knapp S

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 10 Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O94804 (Residues: 18-317; Coverage: 31%)
Gene names: LOK, STK10
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: I222
Unit cell:
a: 49.192Å b: 112.96Å c: 133.817Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.204 0.235
Expression system: Escherichia coli BL21(DE3)