› 2j6x

X-ray diffraction
2.1Å resolution

The crystal structure of lactate oxidase

Released:
DOI: 10.2210/pdb2j6x/pdb
PDB entry 2j6x coloured by chain, front view.
PDB entry 2j6x coloured by chain, side view.
PDB entry 2j6x coloured by chain, top view.
Source organism: Aerococcus viridans
Primary publication:
The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX).
Leiros I, Wang E, Rasmussen T, Oksanen E, Repo H, Petersen SB, Heikinheimo P, Hough E
Acta Crystallogr Sect F Struct Biol Cryst Commun 62 1185-90 (2006)
PMID: 17142893

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175022 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-lactate oxidase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 374 amino acids
Theoretical weight: 40.91 KDa
Source organism: Aerococcus viridans
UniProt:
  • Canonical: Q44467 (Residues: 1-374; Coverage: 100%)
Sequence domains: FMN-dependent dehydrogenase
Structure domains: Aldolase class I

Ligands and Environments

2 bound ligands:
Ligand FMN 8 x FMN
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 117.34Å b: 134.74Å c: 185.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.2 0.257

Quick links

Citations

15 citation in other articles

Cyanobacterial lactate oxidases serve as essential partners in N2 fixation and evolved into photorespiratory glycolate oxidases in plants.
Hackenberg et al. (2011)
14 more

3 mentions without citation

Structure of human glycolate oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole.
Bourhis et al. (2009)
2 more