X-ray diffraction
2.1Å resolution

Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
STE20-like serine/threonine-protein kinase Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 37.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9H2G2 (Residues: 12-15, 16-320; Coverage: 25%)
Gene names: KIAA0204, SLK, STK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6122
Unit cell:
a: 101.195Å b: 101.195Å c: 177.173Å
α: 90° β: 90° γ: 120°
R R work R free
0.202 0.201 0.233
Expression system: Escherichia coli BL21(DE3)