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Crystal structure of Staphylococcus aureus guanylate monophosphate kinase

Source organism: Staphylococcus aureus
Biochemical function: transferase activity
Biological process: GDP metabolic process
Cellular component: cytosol

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EC 2.7.4.8: Guanylate kinase

Reaction catalysed:
ATP + GMP = ADP + GDP
Systematic name:
ATP:(d)GMP phosphotransferase
Alternative Name(s):
  • 5'-GMP kinase
  • ATP:GMP phosphotransferase
  • Deoxyguanylate kinase
  • GMP kinase
  • Guanosine monophosphate kinase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00625
Domain description: Guanylate kinase
Occurring in:
  1. Guanylate kinase
The deposited structure of PDB entry 2j41 contains 4 copies of Pfam domain PF00625 (Guanylate kinase) in Guanylate kinase. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR008145
Domain description: Guanylate kinase/L-type calcium channel beta subunit
Occurring in:
  1. Guanylate kinase
IPR017665
Domain description: Guanylate kinase
Occurring in:
  1. Guanylate kinase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Guanylate kinase
IPR020590
Domain description: Guanylate kinase, conserved site
Occurring in:
  1. Guanylate kinase
IPR008144
Domain description: Guanylate kinase-like domain
Occurring in:
  1. Guanylate kinase

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Guanylate kinase
The deposited structure of PDB entry 2j41 contains 4 copies of CATH domain 3.40.50.300 (Rossmann fold) in Guanylate kinase. Showing 1 copy in chain D.
3.30.63.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Guanylate Kinase phosphate binding domain
Homology: Guanylate Kinase phosphate binding domain
Occurring in:
  1. Guanylate kinase
The deposited structure of PDB entry 2j41 contains 4 copies of CATH domain 3.30.63.10 (Guanylate Kinase phosphate binding domain) in Guanylate kinase. Showing 1 copy in chain D.

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