Function and Biology

Crystal structure of Human Cytosolic 5'-Nucleotidase II (NT5C2, cN-II)

Source organism: Homo sapiens
Biochemical function: XMP 5'-nucleosidase activity
Biological process: protein K48-linked ubiquitination
Cellular component: cytosol

EC 3.1.3.99: IMP-specific 5'-nucleotidase

Reaction catalysed:
IMP + H(2)O = inosine + phosphate
Systematic name:
Inosine 5'-phosphate phosphohydrolase
Alternative Name(s):
  • ISN1 (gene name)

EC 3.1.3.5: 5'-nucleotidase

Reaction catalysed:
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate
Systematic name:
5'-ribonucleotide phosphohydrolase
Alternative Name(s):
  • 5'-AMP nucleotidase
  • 5'-AMPase
  • 5'-adenylic phosphatase
  • 5'-mononucleotidase
  • AMP phosphatase
  • AMP phosphohydrolase
  • AMPase
  • Adenosine 5'-phosphatase
  • Adenosine monophosphatase
  • IMP 5'-nucleotidase
  • Snake venom 5'-nucleotidase
  • Thimidine monophosphate nucleotidase
  • UMPase
  • Uridine 5'-nucleotidase

EC 2.7.1.77: Nucleoside phosphotransferase

Reaction catalysed:
A nucleotide + a 2'-deoxynriboucleoside = a nucleoside + a 2'-deoxyribonucleoside 5'-phosphate
Systematic name:
Nucleotide:nucleoside 5'-phosphotransferase
Alternative Name(s):
  • Nonspecific nucleoside phosphotransferase
  • Nucleotide:2'-nucleoside 5'-phosphotransferase
  • Nucleotide:3'-deoxynucleoside 5'-phosphotransferase

Sequence family

Pfam Protein family (Pfam)
PF05761
Domain description: 5' nucleotidase family
Occurring in:
  1. Cytosolic purine 5'-nucleotidase
The deposited structure of PDB entry 2j2c contains 1 copy of Pfam domain PF05761 (5' nucleotidase family) in Cytosolic purine 5'-nucleotidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008380
Domain description: HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase
Occurring in:
  1. Cytosolic purine 5'-nucleotidase
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. Cytosolic purine 5'-nucleotidase
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. Cytosolic purine 5'-nucleotidase
IPR016695
Domain description: Purine 5'-nucleotidase
Occurring in:
  1. Cytosolic purine 5'-nucleotidase