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Structure of the catalytic domain of mouse Manic Fringe in complex with UDP and manganese

Source organism: Mus musculus
Biochemical function: glycosyltransferase activity
Biological process: not assigned
Cellular component: membrane

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EC 2.4.1.222: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Reaction catalysed:
UDP-N-acetyl-alpha-D-glucosamine + [protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine) = UDP + [protein]-3-O-(N-acteyl-beta-D-glucosamine-(1->3)-alpha-L-fucosyl)-(L-serine/L-threonine)
Systematic name:
UDP-N-acetyl-alpha-D-glucosamine:[protein with EGF-like domain]-3-O-(alpha-L-fucosyl)-(L-serine/L-threonine) 3-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Alternative Name(s):
  • O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF02434
Domain description: Fringe-like
Occurring in:
  1. Beta-1,3-N-acetylglucosaminyltransferase manic fringe
The deposited structure of PDB entry 2j0b contains 1 copy of Pfam domain PF02434 (Fringe-like) in Beta-1,3-N-acetylglucosaminyltransferase manic fringe. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Beta-1,3-N-acetylglucosaminyltransferase manic fringe
IPR003378
Domain description: Fringe-like, glycosyltransferase domain
Occurring in:
  1. Beta-1,3-N-acetylglucosaminyltransferase manic fringe

Structure domain

CATH CATH domain
3.90.550.50
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Occurring in:
  1. Beta-1,3-N-acetylglucosaminyltransferase manic fringe
The deposited structure of PDB entry 2j0b contains 1 copy of CATH domain 3.90.550.50 (Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A) in Beta-1,3-N-acetylglucosaminyltransferase manic fringe. Showing 1 copy in chain A.

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