X-ray diffraction
1.7Å resolution

The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Oleandomycin glycosyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 415 amino acids
Theoretical weight: 45.39 KDa
Source organism: Streptomyces antibioticus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q53685 (Residues: 1-415; Coverage: 97%)
Gene names: UGT102A2, oleD
Sequence domains: UDP-glucoronosyl and UDP-glucosyl transferase
Structure domains: Glycogen Phosphorylase B;

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P21
Unit cell:
a: 72.718Å b: 65.778Å c: 91.94Å
α: 90° β: 100.42° γ: 90°
R R work R free
0.201 0.2 0.232
Expression system: Escherichia coli BL21(DE3)