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crystal structure of RluD from E. coli

Source organism: Escherichia coli
Biochemical function: 23S rRNA pseudouridine(1911/1915/1917) synthase activity
Biological process: RNA modification
Cellular component: cytosol

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EC 5.4.99.23: 23S rRNA pseudouridine(1911/1915/1917) synthase

Reaction catalysed:
23S rRNA uridine(1911)/uridine(1915)/uridine(1917) = 23S rRNA pseudouridine(1911)/pseudouridine(1915)/pseudouridine(1917)
Systematic name:
23S rRNA-uridine(1911/1915/1917) uracil mutase
Alternative Name(s):
  • Pseudouridine synthase RluD
  • RluD

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00849
Domain description: RNA pseudouridylate synthase
Occurring in:
  1. Ribosomal large subunit pseudouridine synthase D
The deposited structure of PDB entry 2ist contains 1 copy of Pfam domain PF00849 (RNA pseudouridylate synthase) in Ribosomal large subunit pseudouridine synthase D. Showing 1 copy in chain A.

PF01479
Domain description: S4 domain
Occurring in:
  1. Ribosomal large subunit pseudouridine synthase D
The deposited structure of PDB entry 2ist contains 1 copy of Pfam domain PF01479 (S4 domain) in Ribosomal large subunit pseudouridine synthase D. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006145
Domain description: Pseudouridine synthase, RsuA/RluA-like
Occurring in:
  1. Ribosomal large subunit pseudouridine synthase D
IPR002942
Domain description: RNA-binding S4 domain
Occurring in:
  1. Ribosomal large subunit pseudouridine synthase D
IPR006224
Domain description: Pseudouridine synthase, RluA-like, conserved site
Occurring in:
  1. Ribosomal large subunit pseudouridine synthase D
IPR020103
Domain description: Pseudouridine synthase, catalytic domain superfamily
Occurring in:
  1. Ribosomal large subunit pseudouridine synthase D
IPR006225
Domain description: Pseudouridine synthase, RluC/RluD
Occurring in:
  1. Ribosomal large subunit pseudouridine synthase D
IPR036986
Domain description: RNA-binding S4 domain superfamily
Occurring in:
  1. Ribosomal large subunit pseudouridine synthase D

Structure domains

CATH CATH domains
6.10.140.230
Class: Special
Architecture: Helix non-globular
Topology: Helix Hairpins
Homology: Helix Hairpins
Occurring in:
  1. Ribosomal large subunit pseudouridine synthase D
The deposited structure of PDB entry 2ist contains 1 copy of CATH domain 6.10.140.230 (Helix Hairpins) in Ribosomal large subunit pseudouridine synthase D. Showing 1 copy in chain A.
3.30.2350.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Pseudouridine synthase
Homology: Pseudouridine synthase
Occurring in:
  1. Ribosomal large subunit pseudouridine synthase D
The deposited structure of PDB entry 2ist contains 1 copy of CATH domain 3.30.2350.10 (Pseudouridine synthase) in Ribosomal large subunit pseudouridine synthase D. Showing 1 copy in chain A.
3.10.290.10
Class: Alpha Beta
Architecture: Roll
Topology: Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A
Homology: RNA-binding S4 domain
Occurring in:
  1. Ribosomal large subunit pseudouridine synthase D
The deposited structure of PDB entry 2ist contains 1 copy of CATH domain 3.10.290.10 (Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A) in Ribosomal large subunit pseudouridine synthase D. Showing 1 copy in chain A.

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