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Crystal structure of human PPM1K

X-ray diffraction
2.25Å resolution
PDB entry 2iq1 coloured by chain, front view.
PDB entry 2iq1 coloured by chain, side view.
PDB entry 2iq1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein phosphatase Mn(2+)-dependent 1K
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Multimeric state: monomeric
Accessible surface area: 11514.63 Å2
Buried surface area: 112.3 Å2
Dissociation area: 56.15 Å2
Dissociation energy (ΔGdiss): 8.73 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-185378

Macromolecules

Protein phosphatase Mn(2+)-dependent 1K
Chain: A
Length: 274 amino acids
Theoretical weight: 30.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N3J5 (Residues: 89-351; Coverage: 71%)
Gene names: PP2CM, PPM1K
Pfam: Protein phosphatase 2C
InterPro:
CATH: PPM-type phosphatase domain
Protein phosphatase Mn(2+)-dependent 1K in PDB entry 2iq1, assembly 1, front view.
Protein phosphatase Mn(2+)-dependent 1K in PDB entry 2iq1, assembly 1, side view.
Protein phosphatase Mn(2+)-dependent 1K in PDB entry 2iq1, assembly 1, top view.
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