PDBe 2ipx

X-ray diffraction
1.82Å resolution

Human Fibrillarin

Released:
Source organism: Homo sapiens
Entry authors: Min J, Wu H, Zeng H, Loppnau P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
rRNA 2'-O-methyltransferase fibrillarin Chain: A
Molecule details ›
Chain: A
Length: 233 amino acids
Theoretical weight: 25.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22087 (Residues: 83-315; Coverage: 73%)
Gene names: FBL, FIB1, FLRN
Sequence domains: Fibrillarin
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41212
Unit cell:
a: 57.261Å b: 57.261Å c: 135.028Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.246
Expression system: Escherichia coli