2ipt

X-ray diffraction
2Å resolution

PFA1 Fab Fragment

Released:
Source organism: Mus musculus
Primary publication:
Molecular basis for passive immunotherapy of Alzheimer's disease.
Proc Natl Acad Sci U S A 104 15659-64 (2007)
PMID: 17895381

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-106883 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.15 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: A2NHM3 (Residues: 1-219; Coverage: 100%)
Gene names: Igk-C, Igkc
Sequence domains:
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 223 amino acids
Theoretical weight: 23.81 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q6PIP8 (Residues: 20-54, 55-117, 118-122, 123-234; Coverage: 48%)
Gene name: Igh
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P1
Unit cell:
a: 41.985Å b: 42.825Å c: 58.381Å
α: 95.84° β: 94.77° γ: 91.91°
R-values:
R R work R free
0.18 0.177 0.223