2il1

X-ray diffraction
2.1Å resolution

Crystal structure of a predicted human GTPase in complex with GDP

Released:
Source organism: Homo sapiens
Entry authors: Wang J, Shen Y, Tempel W, Landry R, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-12 Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 21.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6IQ22 (Residues: 36-208; Coverage: 71%)
Gene name: RAB12
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P6522
Unit cell:
a: 45.463Å b: 45.463Å c: 315.454Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.241 0.241 0.266
Expression system: Escherichia coli