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Crystal Structure of Human Renin Complexed with Inhibitor

X-ray diffraction
1.9Å resolution
PDB entry 2iko coloured by chain, front view.
PDB entry 2iko coloured by chain, side view.
PDB entry 2iko coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Renin
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Multimeric state: homo hexamer
Accessible surface area: 72627.19 Å2
Buried surface area: 18036.13 Å2
Dissociation area: 8,958.92 Å2
Dissociation energy (ΔGdiss): 23.91 kcal/mol
Dissociation entropy (TΔSdiss): 72.31 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-133570

Macromolecules

Renin
Chains: A, B
Length: 340 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00797 (Residues: 67-406; Coverage: 89%)
Gene name: REN
Pfam: Eukaryotic aspartyl protease
InterPro:
CATH: Acid Proteases
Renin in PDB entry 2iko, assembly 1, front view.
Renin in PDB entry 2iko, assembly 1, side view.
Renin in PDB entry 2iko, assembly 1, top view.
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