Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
High affinity nerve growth factor receptor
Molecule details ›
Chains: A, B
Length: 347 amino acids
Theoretical weight: 37.9 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Leucine rich repeat C-terminal motif
Structure domains:
Length: 347 amino acids
Theoretical weight: 37.9 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P04629 (Residues: 36-382; Coverage: 45%)
Sequence domains: Leucine rich repeat C-terminal motif
Structure domains:
Beta-nerve growth factor
Molecule details ›
Chains: E, F
Length: 120 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines
Length: 120 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P01138 (Residues: 122-241; Coverage: 54%)
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SSRL BEAMLINE BL11-1
Spacegroup:
P21
Expression system: Spodoptera frugiperda
