Assemblies
Multimeric state:
hetero trimer
Accessible surface area:
75078.59 Å2
Buried surface area:
13851.3 Å2
Dissociation area:
1,474.43
Å2
Dissociation energy (ΔGdiss):
-7.27
kcal/mol
Dissociation entropy (TΔSdiss):
12.76
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-133835
Macromolecules
Chain: A
Length: 642 amino acids
Theoretical weight: 71.17 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 642 amino acids
Theoretical weight: 71.17 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P01024 (Residues: 23-664; Coverage: 39%)
Pfam:
- Macroglobulin domain MG1
- MG2 domain
- Macroglobulin domain MG3
- Macroglobulin domain MG4
- Alpha-2-macroglobulin bait region domain
Chain: B
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P01024 (Residues: 749-1663; Coverage: 56%)
Pfam:
- Alpha-2-macroglobulin family
- Complement component 3, CUB domain 1
- A-macroglobulin TED domain
- Complement component 3, CUB domain 2
- A-macroglobulin receptor binding domain
- UNC-6/NTR/C345C module
- Immunoglobulin-like fold
- Alpha-2-macroglobulin
- Alpha-macroglobulin-like, TED domain
- Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
- Alpha-macroglobulin-like, thiol-ester bond-forming region
- Alpha-2-macroglobulin, conserved site
- Alpha-macroglobulin, receptor-binding domain superfamily
- Alpha-macroglobulin, receptor-binding
- Tissue inhibitor of metalloproteinases-like, OB-fold
- Complement C3-like, NTR domain
- Netrin domain
- Netrin module, non-TIMP type
Chain: S
Length: 119 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Pfam: Immunoglobulin V-set domain
InterPro:
Length: 119 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9Y279 (Residues: 19-137; Coverage: 31%)
Pfam: Immunoglobulin V-set domain
InterPro: