› › Structure analysis

Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+

X-ray diffraction
2.55Å resolution
PDB entry 2i9p coloured by chain, front view.
PDB entry 2i9p coloured by chain, side view.
PDB entry 2i9p coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
hide full assembly name
Multimeric state: homo tetramer
Accessible surface area: 38214.15 Å2
Buried surface area: 18645.14 Å2
Dissociation area: 2,029.1 Å2
Dissociation energy (ΔGdiss): 21.74 kcal/mol
Dissociation entropy (TΔSdiss): 14.92 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-152107

Macromolecules

3-hydroxyisobutyrate dehydrogenase, mitochondrial
Chains: A, B, C, D
Length: 319 amino acids
Theoretical weight: 33.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31937 (Residues: 40-336; Coverage: 88%)
Gene name: HIBADH
Pfam:
InterPro:
CATH:
3-hydroxyisobutyrate dehydrogenase, mitochondrial in PDB entry 2i9p, assembly 1, front view.
3-hydroxyisobutyrate dehydrogenase, mitochondrial in PDB entry 2i9p, assembly 1, side view.
3-hydroxyisobutyrate dehydrogenase, mitochondrial in PDB entry 2i9p, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links