› 2i7n

X-ray diffraction
1.9Å resolution

Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA

Released:
DOI: 10.2210/pdb2i7n/pdb
PDB 2i7n coloured by chain and viewed from the front.
PDB 2i7n coloured by chain and viewed from the side.
PDB 2i7n coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
Hong BS, Senisterra G, Rabeh WM, Vedadi M, Leonardi R, Zhang YM, Rock CO, Jackowski S, Park HW
J. Biol. Chem. 282 27984-93 (2007)
PMID: 17631502

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantothenate kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 360 amino acids
Theoretical weight: 40.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8TE04 (Residues: 234-593; Coverage: 60%)
Gene names: PANK, PANK1
Sequence domains: Fumble
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ACO 2 x ACO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM, null
Spacegroup: P63
Unit cell:
a: 92.989Å b: 92.989Å c: 197.782Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.222 0.243
Expression system: Escherichia coli BL21(DE3)

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Citations

8 review citations

Exploring Missense Mutations in Tyrosine Kinases Implicated with Neurodegeneration.
Sami et al. (2017)
7 more

3 mentions without citation

Human pantothenate kinase 4 is a pseudo-pantothenate kinase.
Yao et al. (2019)
2 more