X-ray diffraction
1.9Å resolution

Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA


Function and Biology Details

Reaction catalysed:
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Pantothenate kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 360 amino acids
Theoretical weight: 40.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q8TE04 (Residues: 234-593; Coverage: 60%)
Gene names: PANK, PANK1
Sequence domains: Fumble
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM, null
Spacegroup: P63
Unit cell:
a: 92.989Å b: 92.989Å c: 197.782Å
α: 90° β: 90° γ: 120°
R R work R free
0.25 0.222 0.243
Expression system: Escherichia coli BL21(DE3)