› 2i6t

X-ray diffraction
2.1Å resolution

Orthorhombic Structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A

Released:
DOI: 10.2210/pdb2i6t/pdb
PDB entry 2i6t coloured by chain, front view.
PDB entry 2i6t coloured by chain, side view.
PDB entry 2i6t coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Walker JR, Avvakumov GV, Xue S, Newman EM, Finerty Jr PJ, Butler-Cole C, Tempel W, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Dhe-Paganon S

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184905 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin-conjugating enzyme E2 variant 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 303 amino acids
Theoretical weight: 32.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IX04 (Residues: 171-471; Coverage: 64%)
Gene names: UEV3, UEVLD
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand GOL 7 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 53.088Å b: 98.912Å c: 126.753Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.18 0.23
Expression system: Escherichia coli BL21(DE3)

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