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Crystal Structure of Human Inosine Triphosphate Pyrophosphatase

Source organism: Homo sapiens
Biochemical function: nucleoside triphosphate diphosphatase activity
Biological process: chromosome organization
Cellular component: intracellular membrane-bounded organelle

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EC 3.6.1.9: Nucleotide diphosphatase

Reaction catalysed:
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate
Systematic name:
Nucleoside-triphosphate diphosphohydrolase
Alternative Name(s):
  • Dinucleotide nucleotidohydrolase
  • ENPP1 (gene name)
  • Nucleoside-triphosphate diphosphatase
  • Nucleotide pyrophosphatase
  • Nucleotide-sugar pyrophosphatase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01725
Domain description: Ham1 family
Occurring in:
  1. Inosine triphosphate pyrophosphatase
The deposited structure of PDB entry 2i5d contains 1 copy of Pfam domain PF01725 (Ham1 family) in Inosine triphosphate pyrophosphatase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002637
Domain description: RdgB/HAM1
Occurring in:
  1. Inosine triphosphate pyrophosphatase
IPR029001
Domain description: Inosine triphosphate pyrophosphatase-like
Occurring in:
  1. Inosine triphosphate pyrophosphatase
IPR027502
Domain description: Inosine triphosphate pyrophosphatase
Occurring in:
  1. Inosine triphosphate pyrophosphatase

Structure domain

CATH CATH domain
3.90.950.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Maf protein
Homology: Maf protein
Occurring in:
  1. Inosine triphosphate pyrophosphatase
The deposited structure of PDB entry 2i5d contains 1 copy of CATH domain 3.90.950.10 (Maf protein) in Inosine triphosphate pyrophosphatase. Showing 1 copy in chain A.
SCOP SCOP annotation
52973
Class: Alpha and beta proteins (a/b)
Fold: Anticodon-binding domain-like
Superfamily: ITPase-like
Occurring in:
  1. Inosine triphosphate pyrophosphatase
The deposited structure of PDB entry 2i5d contains 1 copy of SCOP domain 52973 (ITPase (Ham1)) in Inosine triphosphate pyrophosphatase. Showing 1 copy in chain A.

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