X-ray diffraction
2.15Å resolution

Structural studies of protein tyrosine phosphatase beta catalytic domain co-crystallized with a sulfamic acid inhibitor


Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Receptor-type tyrosine-protein phosphatase beta Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 36.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P23467 (Residues: 1662-1973; Coverage: 16%)
Gene names: PTPB, PTPRB
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 113.313Å b: 38.795Å c: 66.983Å
α: 90° β: 104.94° γ: 90°
R R work R free
0.173 0.169 0.246
Expression system: Escherichia coli