EC 3.4.24.86: ADAM 17 endopeptidase
Reaction catalysed:
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
Systematic name:
-
Alternative Name(s):
- TACE
- Tumor necrosis factor alpha-converting enzyme
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned