X-ray diffraction
2.9Å resolution

rat DPP-IV with xanthine mimetic inhibitor #7


Function and Biology Details

Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo hexamer
Entry contents:
1 distinct polypeptide molecule
Dipeptidyl peptidase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 730 amino acids
Theoretical weight: 84.34 KDa
Source organism: Rattus norvegicus
  • Canonical: P14740 (Residues: 38-767; Coverage: 95%)
Gene names: Cd26, Dpp4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P213
Unit cell:
a: 207.293Å b: 207.293Å c: 207.293Å
α: 90° β: 90° γ: 90°
R R work R free
0.253 0.253 0.29