› 2hyw

X-ray diffraction
2.1Å resolution

Human Annexin A2 with Calcium bound

Released:
DOI: 10.2210/pdb2hyw/pdb
PDB entry 2hyw coloured by chain, front view.
PDB entry 2hyw coloured by chain, side view.
PDB entry 2hyw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic analysis of calcium-dependent heparin binding to annexin A2.
Shao C, Zhang F, Kemp MM, Linhardt RJ, Waisman DM, Head JF, Seaton BA
J Biol Chem 281 31689-95 (2006)
PMID: 16882661

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139552 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin A2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 308 amino acids
Theoretical weight: 35.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07355 (Residues: 32-339; Coverage: 91%)
Gene names: ANX2, ANX2L4, ANXA2, CAL1H, LPC2D
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

1 bound ligand:
Ligand CA 14 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 60.509Å b: 64.283Å c: 104.158Å
α: 90° β: 91.73° γ: 90°
R-values:
R R work R free
0.214 0.214 0.257
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

The structure of glycosaminoglycans and their interactions with proteins.
Gandhi et al. (2008)
10 more

13 mentions without citation

In silico structure-based approaches to discover protein-protein interaction-targeting drugs.
Shin et al. (2017)
12 more