Structure analysis

Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain

X-ray diffraction
2.45Å resolution
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 15200 Å2
Buried surface area: 550 Å2
Dissociation area: 100 Å2
Dissociation energy (ΔGdiss): 2 kcal/mol
Dissociation entropy (TΔSdiss): -1 kcal/mol
Interface energy (ΔGint): -1 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 320 amino acids
Theoretical weight: 36.24 KDa
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WIJ1 (Residues: 1003-1322; Coverage: 17%)
Gene name: NS
InterPro: Alphavirus nsp2 protease (nsp2pro) domain
CATH:

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