› 2hwk

X-ray diffraction
2.45Å resolution

Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain

Released:
DOI: 10.2210/pdb2hwk/pdb
PDB 2hwk coloured by chain and viewed from the front.
PDB 2hwk coloured by chain and viewed from the side.
PDB 2hwk coloured by chain and viewed from the top.
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Primary publication:
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
Russo AT, White MA, Watowich SJ
Structure 14 1449-58 (2006)
PMID: 16962975

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
helicase nsP2 Chain: A
Molecule details ›
Chain: A
Length: 320 amino acids
Theoretical weight: 36.24 KDa
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WIJ1 (Residues: 1003-1322; Coverage: 17%)
Gene name: NS
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FMT 3 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CAMD BEAMLINE GCPCC
Spacegroup: P212121
Unit cell:
a: 47.47Å b: 72.58Å c: 106.66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.192 0.242
Expression system: Escherichia coli

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Citations

7 review citations

The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies.
Wong et al. (2018)
6 more

10 mentions without citation

Expanding Repertoire of Plant Positive-Strand RNA Virus Proteases.
Mann et al. (2019)
9 more