X-ray diffraction
2.55Å resolution

The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1

Source organism: Homo sapiens
Entry authors: Turnbull AP, Salah E, Niesen F, Debreczeni J, Ugochukwu E, Pike ACW, Kavanagh K, Gileadi O, Gorrec F, Umeano C, von Delft F, Weigelt J, Edwards A, Arrowsmith C, Sundstrom M, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed:
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Enoyl-CoA hydratase, mitochondrial Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 286 amino acids
Theoretical weight: 31.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P30084 (Residues: 28-290; Coverage: 91%)
Gene name: ECHS1
Sequence domains: Enoyl-CoA hydratase/isomerase
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 91.554Å b: 97.344Å c: 231.796Å
α: 90° β: 90° γ: 90°
R R work R free
0.216 0.214 0.252
Expression system: Escherichia coli