2hu0

X-ray diffraction
2.95Å resolution

N1 neuraminidase in complex with oseltamivir 1

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuraminidase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 387 amino acids
Theoretical weight: 42.43 KDa
Source organism: Influenza A virus
UniProt:
  • Canonical: Q6DPL2 (Residues: 63-449; Coverage: 86%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2221
Unit cell:
a: 198.083Å b: 200.576Å c: 210.417Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.218 0.295