› 2hnx

X-ray diffraction
1.5Å resolution

Crystal Structure of aP2

Released:
DOI: 10.2210/pdb2hnx/pdb
PDB 2hnx coloured by chain and viewed from the front.
PDB 2hnx coloured by chain and viewed from the side.
PDB 2hnx coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Marr E, Tardie M, Carty M, Brown Phillips T, Qiu X, Karam G

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein, adipocyte Chain: A
Molecule details ›
Chain: A
Length: 136 amino acids
Theoretical weight: 15.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15090 (Residues: 1-132; Coverage: 100%)
Gene name: FABP4
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

3 bound ligands:
Ligand PO4 1 x PO4
Ligand PLM 1 x PLM
Ligand ACY 2 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 32.47Å b: 53.94Å c: 75Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.174 0.225
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Unveiling the Role of the Fatty Acid Binding Protein 4 in the Metabolic-Associated Fatty Liver Disease.
Moreno-Vedia et al. (2022)
1 more

8 mentions without citation

Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases.
Furuhashi et al. (2014)
7 more