› 2hlz

X-ray diffraction
1.85Å resolution

Crystal Structure of human ketohexokinase

Released:
DOI: 10.2210/pdb2hlz/pdb
PDB entry 2hlz coloured by chain, front view.
PDB entry 2hlz coloured by chain, side view.
PDB entry 2hlz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rabeh WM, Tempel W, Nedyalkova L, Landry R, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + D-fructose = ADP + D-fructose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156120 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ketohexokinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 312 amino acids
Theoretical weight: 34.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50053 (Residues: 5-298; Coverage: 99%)
Gene name: KHK
Sequence domains: pfkB family carbohydrate kinase
Structure domains: UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase

Ligands and Environments

1 bound ligand:
Ligand UNX 32 x UNX
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P1
Unit cell:
a: 66.933Å b: 71.672Å c: 82.694Å
α: 105.06° β: 107.33° γ: 93.09°
R-values:
R R work R free
0.216 0.214 0.249
Expression system: Escherichia coli

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