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Crystal structure of the A49M mutant CAP-Gly domain of human Dynactin-1 (p150-Glued) in complex with human EB1 C-terminal hexapeptide

X-ray diffraction
2.03Å resolution
PDB entry 2hl3 coloured by chain, front view.
PDB entry 2hl3 coloured by chain, side view.
PDB entry 2hl3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dynactin subunit 1 and Microtubule-associated protein RP/EB family member 1
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Multimeric state: hetero trimer
Accessible surface area: 8791.04 Å2
Buried surface area: 4189.23 Å2
Dissociation area: 382.67 Å2
Dissociation energy (ΔGdiss): -0.47 kcal/mol
Dissociation entropy (TΔSdiss): 4.71 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-171967

Macromolecules

Dynactin subunit 1
Chains: A, B
Length: 97 amino acids
Theoretical weight: 10.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14203 (Residues: 18-111; Coverage: 7%)
Gene name: DCTN1
Pfam: CAP-Gly domain
InterPro:
CATH: CAP Gly-rich-like domain
Dynactin subunit 1 in PDB entry 2hl3, assembly 1, front view.
Dynactin subunit 1 in PDB entry 2hl3, assembly 1, side view.
Dynactin subunit 1 in PDB entry 2hl3, assembly 1, top view.
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Microtubule-associated protein RP/EB family member 1
Chain: C
Length: 6 amino acids
Theoretical weight: 826 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15691 (Residues: 263-268; Coverage: 2%)
Gene name: MAPRE1
Microtubule-associated protein RP/EB family member 1 in PDB entry 2hl3, assembly 1, front view.
Microtubule-associated protein RP/EB family member 1 in PDB entry 2hl3, assembly 1, side view.
Microtubule-associated protein RP/EB family member 1 in PDB entry 2hl3, assembly 1, top view.
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