X-ray diffraction
1.95Å resolution

Crystal Structure of Human Microsomal P450 1A2 in complex with alpha-naphthoflavone


Function and Biology Details

Reactions catalysed:
A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H(2)O
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O
Biochemical function:
Biological process:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cytochrome P450 1A2 Chain: A
Molecule details ›
Chain: A
Length: 495 amino acids
Theoretical weight: 56.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P05177 (Residues: 27-516; Coverage: 95%)
Gene name: CYP1A2
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

Cofactor: Ligand HEM 1 x HEM
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: I222
Unit cell:
a: 79.63Å b: 80.82Å c: 175.82Å
α: 90° β: 90° γ: 90°
R R work R free
0.223 0.226 0.267
Expression system: Escherichia coli