› 2hhm

X-ray diffraction
2.1Å resolution

STRUCTURE OF INOSITOL MONOPHOSPHATASE, THE PUTATIVE TARGET OF LITHIUM THERAPY

Released:
DOI: 10.2210/pdb2hhm/pdb
PDB entry 2hhm coloured by chain, front view.
PDB entry 2hhm coloured by chain, side view.
PDB entry 2hhm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of inositol monophosphatase, the putative target of lithium therapy.
Bone R, Springer JP, Atack JR
Proc Natl Acad Sci U S A 89 10031-5 (1992)
PMID: 1332026

Function and Biology Details

Reactions catalysed: 
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
Alpha-D-galactose 1-phosphate + H(2)O = D-galactose + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151370 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol monophosphatase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 30.09 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P29218 (Residues: 2-277; Coverage: 100%)
Gene names: IMPA, IMPA1
Sequence domains: Inositol monophosphatase family
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand GD 2 x GD
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3221
Unit cell:
a: 86.2Å b: 86.2Å c: 154.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.166 not available not available
Expression system: Not provided

Quick links

Citations

8 review citations

Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers.
Gould et al. (2004)
7 more

6 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
5 more