Function and Biology

Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.

Source organism: Saccharopolyspora erythraea
Biochemical function: 3-oxoacyl-[acyl-carrier-protein] synthase activity
Biological process: fatty acid biosynthetic process
Cellular component: not assigned

EC 2.3.1.94: 6-deoxyerythronolide-B synthase

Reaction catalysed:
Propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH = 6-deoxyerythronolide B + 7 CoA + 6 CO(2) + H(2)O + 6 NADP(+)
Systematic name:
Propanoyl-CoA:(2S)-methylmalonyl-CoA malonyltransferase (cyclizing)
Alternative Name(s):
  • 6-deoxyerythronolide B synthase
  • DEBS
  • Deoxyerythronolide B synthase
  • Erythronolide synthase
  • Erythronolide-condensing enzyme
  • Malonyl-CoA:propanoyl-CoA malonyltransferase (cyclizing)
  • Malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF08990
Domain description: Erythronolide synthase docking domain
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6

PF00109
Domain description: Beta-ketoacyl synthase, N-terminal domain
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6

PF16197
Domain description: Ketoacyl-synthetase C-terminal extension
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6

PF02801
Domain description: Beta-ketoacyl synthase, C-terminal domain
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6

PF00698
Domain description: Acyl transferase domain
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6

InterPro InterPro annotations
IPR016039
Domain description: Thiolase-like
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
IPR016036
Domain description: Malonyl-CoA ACP transacylase, ACP-binding
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
IPR016035
Domain description: Acyl transferase/acyl hydrolase/lysophospholipase
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
IPR015083
Domain description: Polyketide synthase, docking domain
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
IPR032821
Domain description: Polyketide synthase, C-terminal extension
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
IPR014031
Domain description: Beta-ketoacyl synthase, C-terminal
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
IPR014030
Domain description: Beta-ketoacyl synthase, N-terminal
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
IPR020841
Domain description: Polyketide synthase, beta-ketoacyl synthase domain
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
IPR036299
Domain description: Polyketide synthase, docking domain superfmaily
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
IPR001227
Domain description: Acyl transferase domain superfamily
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
IPR014043
Domain description: Acyl transferase
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6

Structure domains

CATH CATH domains
3.30.70.3290
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
3.40.47.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Peroxisomal Thiolase; Chain A, domain 1
Homology: Peroxisomal Thiolase; Chain A, domain 1
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6
3.40.366.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Malonyl-Coenzyme A Acyl Carrier Protein; domain 2
Homology: Malonyl-Coenzyme A Acyl Carrier Protein, domain 2
Occurring in:
  1. 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6