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Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine NAAPD synthesis and hydrolysis activities

Source organism: Homo sapiens
Biochemical function: NAD+ nucleotidase, cyclic ADP-ribose generating
Biological process: not assigned
Cellular component: not assigned

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EC 3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

Reaction catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Systematic name:
NAD(+) glycohydrolase (cyclic ADP-ribose-forming)
Alternative Name(s):
  • BST1 (gene name)
  • CD38 (gene name)
  • DPN hydrolase
  • DPNase
  • NAD glycohydrolase
  • NAD hydrolase
  • NAD nucleosidase
  • NAD(+) nucleosidase
  • NADase
  • Nicotinamide adenine dinucleotide glycohydrolase
  • Nicotinamide adenine dinucleotide nucleosidase

EC 2.4.99.20: 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

Reaction catalysed:
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
Systematic name:
NADP(+):nicotinate ADP-ribosyltransferase
Alternative Name(s):
  • BST1 (gene name)
  • CD38 (gene name)
  • Diphosphopyridine nucleosidase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF02267
Domain description: ADP-ribosyl cyclase
Occurring in:
  1. ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
The deposited structure of PDB entry 2hct contains 2 copies of Pfam domain PF02267 (ADP-ribosyl cyclase) in ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. Showing 1 copy in chain A.

InterPro InterPro annotation
IPR003193
Domain description: ADP-ribosyl cyclase (CD38/157)
Occurring in:
  1. ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Structure domains

CATH CATH domains
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
The deposited structure of PDB entry 2hct contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. Showing 1 copy in chain A.
1.20.82.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: ADP Ribosyl Cyclase; Chain A, domain 1
Homology: ADP Ribosyl Cyclase; Chain A, domain 1
Occurring in:
  1. ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
The deposited structure of PDB entry 2hct contains 2 copies of CATH domain 1.20.82.10 (ADP Ribosyl Cyclase; Chain A, domain 1) in ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. Showing 1 copy in chain A.

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