2hc2

X-ray diffraction
1.4Å resolution

Engineered protein tyrosine phosphatase beta catalytic domain

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase beta Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 33.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23467 (Residues: 1676-1970; Coverage: 15%)
Gene names: PTPB, PTPRB
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 38.314Å b: 70.775Å c: 49.846Å
α: 90° β: 92.52° γ: 90°
R-values:
R R work R free
0.146 0.144 0.179
Expression system: Escherichia coli