› 2hak

X-ray diffraction
2.6Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase MARK1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 328 amino acids
Theoretical weight: 37.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P0L2 (Residues: 45-371; Coverage: 41%)
Gene names: KIAA1477, MARK, MARK1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P212121
Unit cell:
a: 110.682Å b: 116.47Å c: 285.748Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.29
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Regulation of Cell Polarity by PAR-1/MARK Kinase.
Wu et al. (2017)
6 more

12 mentions without citation

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein.
Timm et al. (2008)
11 more