2h62

X-ray diffraction
1.85Å resolution

Crystal structure of a ternary ligand-receptor complex of BMP-2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Bone morphogenetic protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 114 amino acids
Theoretical weight: 12.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12643 (Residues: 283-396; Coverage: 31%)
Gene names: BMP2, BMP2A
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Bone morphogenetic protein receptor type-1A Chain: C
Molecule details ›
Chain: C
Length: 129 amino acids
Theoretical weight: 14.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P36894 (Residues: 24-152; Coverage: 25%)
Gene names: ACVRLK3, ALK3, BMPR1A
Sequence domains: Activin types I and II receptor domain
Structure domains: CD59
Activin receptor type-2B Chain: D
Molecule details ›
Chain: D
Length: 98 amino acids
Theoretical weight: 11.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13705 (Residues: 19-116; Coverage: 20%)
Gene name: ACVR2B
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 64.131Å b: 65.368Å c: 114.067Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.216 0.225
Expression system: Escherichia coli