Function and Biology Details
Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
- NendoU domain, nidovirus
- NSP15, NendoU domain, coronavirus
- Endoribonuclease EndoU-like
- Nonstructural protein 15, middle domain, alpha/betacoronavirus
- Non-structural protein NSP15, middle domain superfamily
- Nonstructural protein 15, middle domain, coronavirus
- Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domain
- Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirus
3 more domains
Structure domains:
Structure analysis Details
Assembly composition:
homo hexamer (preferred)
Assembly name:
RNA-directed RNA polymerase (preferred)
PDBe Complex ID:
PDB-CPX-191572 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-directed RNA polymerase
Molecule details ›
Chain: A
Length: 370 amino acids
Theoretical weight: 41.7 KDa
Source organism: Murine hepatitis virus strain A59
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 370 amino acids
Theoretical weight: 41.7 KDa
Source organism: Murine hepatitis virus strain A59
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9J3E8 (Residues: 2061-2429; Coverage: 14%)
Sequence domains:
- Coronavirus replicase NSP15, N-terminal oligomerisation
- Coronavirus replicase NSP15, middle domain
- Coronavirus replicase NSP15, uridylate-specific endoribonuclease
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU MICROMAX-007
Spacegroup:
P6322
Expression system: Escherichia coli BL21(DE3)
