2gp0

X-ray diffraction
2.05Å resolution

HePTP Catalytic Domain (residues 44-339), S225D mutant

Released:
Source organism: Homo sapiens
Entry author: Page R

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 7 Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 35.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35236 (Residues: 65-360; Coverage: 82%)
Gene name: PTPN7
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P61
Unit cell:
a: 127.52Å b: 127.52Å c: 60.133Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.178 0.206
Expression system: Escherichia coli