Structure analysis

PKA threefold mutant model of Rho-kinase with inhibitor H-1152P

X-ray diffraction
2.6Å resolution
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules


Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 16200 Å2
Buried surface area: 2800 Å2
Dissociation area: 1,400 Å2
Dissociation energy (ΔGdiss): 3 kcal/mol
Dissociation entropy (TΔSdiss): 10 kcal/mol
Interface energy (ΔGint): -2 kcal/mol
Symmetry number: 1


Chain: A
Length: 350 amino acids
Theoretical weight: 40.68 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P00517 (Residues: 2-351; Coverage: 100%)
Gene name: PRKACA
Pfam: Protein kinase domain

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Chain: I
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Oryctolagus cuniculus
Expression system: Not provided
  • Canonical: P61926 (Residues: 6-25; Coverage: 26%)
Gene names: PKIA, PRKACN1
InterPro: cAMP-dependent protein kinase inhibitor

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